Last Updated: Jun 06, 2026
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1. A microbiology laboratory is processing a sputum sample from a patient with chronic cough and night sweats.
After Ziehl-Neelsen staining, acid-fast bacilli are observed. Culture on Lowenstein-Jensen medium is positive after several weeks. Drug susceptibility testing reveals resistance to isoniazid and rifampin. This patient is MOST likely infected with:
A) Actinomyces israelii
B) Multidrug-resistant Mycobacterium tuberculosis
C) Nocardia asteroides
D) Mycobacterium avium complex
2. A patient with a history of travel to an area endemic for schistosomiasis presents with hematuria. Microscopic examination of a urine sediment reveals a large oval egg with a prominent terminal spine. The MOST likely causative agent is:
A) Schistosoma mansoni
B) Schistosoma mekongi
C) Schistosoma japonicum
D) Schistosoma haematobium
3. A patient with a history of neutropenia following chemotherapy develops a rapidly progressive pneumonia.
Bronchoalveolar lavage fluid reveals septate hyphae with acute angle (45-degree) branching. The MOST likely diagnosis is invasive pulmonary aspergillosis caused by:
A) Mucor species
B) Fusarium species
C) Rhizopus species
D) Aspergillus fumigatus
4. A patient develops a severe diarrheal illness after returning from a backpacking trip where they drank untreated stream water. Stool examination reveals motile trophozoites with multiple flagella and a prominent ventral sucking disk. The MOST likely causative agent is:
A) Cyclospora cayetanensis
B) Giardia lamblia
C) Cryptosporidium parvum
D) Entamoeba histolytica
5. A 55-year-old male with a history of poorly controlled diabetes mellitus develops a necrotizing fasciitis of his left lower extremity following a minor abrasion sustained while gardening. Initialcultures of the wound reveal a polymicrobial flora, including Gram-positive cocci in chains and Gram-negative bacilli. Over the next 48 hours, despite broad-spectrum antibiotic therapy, the patient's condition deteriorates, and new bullae with hemorrhagic fluid appear. Gram stain of this fluid now predominantly shows large, Gram-positive bacilli with subterminal spores. Which of the following virulence factors is MOST likely contributing to the rapid tissue destruction observed in this patient?
A) Lipopolysaccharide (LPS)
B) Lecithinase (alpha-toxin)
C) Exotoxin B (SpeB)
D) Protein A
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: D | Question # 3 Answer: D | Question # 4 Answer: B | Question # 5 Answer: B |
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