Updated: Jun 18, 2026
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1. A patient with a history of recurrent sinopulmonary infections and bronchiectasis is diagnosed with primary ciliary dyskinesia. Sputum cultures are most likely to persistently grow which of the following organisms?
A) Haemophilus influenzae
B) Pseudomonas aeruginosa
C) Streptococcus pneumoniae
D) Moraxella catarrhalis
2. Besides traditional Giemsa-stained thick and thin blood smears, which diagnostic approach is commonly employed as a rapid diagnostic test (RDT) for malaria detection, particularly in resource-limited settings?
A) Quantitative Buffy Coat (QBC) analysis
B) Serological detection of anti-Plasmodium IgG antibodies
C) Immunochromatographic assays detecting Plasmodium-specific antigens (e.g., HRP2, pLDH)
D) PCR amplification of Plasmodium 18S rRNA gene directly from saliva
3. A diagnostic laboratory is validating a new multiplex PCR panel for respiratory pathogens. According to CLIA regulations, which of the following parameters must be established by the laboratory performing the validation for this qualitative nucleic acid amplification test?
A) Accuracy, Precision, Clinical Sensitivity, Clinical Specificity
B) Precision, Reportable Range, Analytical Specificity, Reference Interval
C) Accuracy, Precision, Analytical Sensitivity, Analytical Specificity (including cross-reactivity)
D) Accuracy, Precision, Reportable Range, Analytical Sensitivity
4. A patient with a prosthetic joint develops a chronic infection. Multiple synovial fluid cultures grow a Gram- positive coccus that forms a biofilm and is resistant to multiple antibiotics, including methicillin and gentamicin. The MOST likely organism is:
A) Staphylococcus aureus
B) Enterococcus faecium
C) Staphylococcus epidermidis
D) Streptococcus agalactiae
5. A patient presents with a chronic cough, weight loss, and night sweats. Chest X-ray shows cavitarylesions in the upper lobes. Sputum is acid-fast positive. Drug susceptibility testing reveals resistance to isoniazid but susceptibility to rifampin, ethambutol, and pyrazinamide. The MOST appropriate treatment regimen should include:
A) Isoniazid and rifampin
B) Isoniazid, ethambutol, and pyrazinamide
C) Rifampin, ethambutol, and pyrazinamide
D) Isoniazid, rifampin, pyrazinamide, and ethambutol
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: C | Question # 3 Answer: C | Question # 4 Answer: C | Question # 5 Answer: C |
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